Qld FPM June evening lecture

Join us in Brisbane on Monday June 10 for the Queensland FPM June evening lecture.

Guest Speaker

We welcome Emeritus Professor Maree Smith who will present “Biased ligands as potential next generation opioid analgesics”.
Emeritus Professor Maree Smith is Director of the Centre for Integrated Preclinical Drug Development and fulltime researcher in the School of Biomedical Sciences, Faculty of Medicine at The University of Queensland. Internationally, Professor Smith is a leading researcher in biomedical discovery/translation with particular expertise in the novel pain therapeutics field. Professor Smith also has expertise in deriving pharmacokinetic parameters from plasma drug concentration versus time data from animal and early phase human clinical trials and in clinical trial conduct. To date, she has more than 150 peer-reviewed publications and has advised/co-advised more than 30 PhD students and 45 Honours students to completion.

Traditional teaching suggests strong opioid analgesics such as morphine and fentanyl interact with the µ-opioid (MOP) receptor and modulate intracellular signalling via inhibitory G-proteins and b-arrestin2 to produce both analgesia and opioid-related adverse effects. Intriguingly, data showing a marked reduction in respiratory depression and constipation evoked by morphine in mice lacking b-arrestin2, led to the hypothesis that novel “biased”MOP receptor agonists that evoke intracellular signalling via G-protein coupled pathways with reduced signalling via b-arrestin2 coupled pathways, may produce pain relief with significantly reduced opioid-related adverse effects. The first novel biased MOP receptor agonist has completed Phase 3 clinical trials in patients with acute post-operative pain. Several other biased MOP receptor ligands have been discovered and are at the preclinical stage of development. This presentation will provide an overview of work to date in this field.



6.30pm          Drinks and canapes 
7-8pm            Presentation


There is no cost to attend this meeting, but bookings are essential. Please register online today. Trainees and allied health professionals are welcome.
This lecture will also be available to a limited number of delegates to join remotely via Adobe Connect. Please email us if you are interested.


ANZCA QLD regional office
West End Corporate Park, River Tower
20 Pidgeon Close
West End QLD 4101


Continuing professional development (CPD)

This event is ANZCA CPD approved. Members will automatically have their attendance accredited to their CPD portfolio following the meeting.


Proudly supported by Mundipharma


More information

Julie Donovan
P: +61 7 3846 1233
E: qldevents@anzca.edu.au


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