High-flow oxygen during children's airway surgery

High-flow oxygen during children's airway surgery


HAMSTER: High-Flow Oxygen for Children’s Airway Surgery

The HAMSTER trial is a multi-centre project investigating the role of high-flow during paediatric upper airway surgery.

For all the latest updates on HAMSTER, follow @HamsterTrial on Twitter.


Recruitment commenced in September 2018 and is now complete with 530 patients recruited. The study team is cleaning the data and started the audit process. 

Principal investigator

Participating sites

Australian Hospitals
Childrens Hospital At Westmead
Women's and Children's Hospital, SA
Royal Children's Hospital, VIC
Perth Children's Hospital
Queensland Children's Hospital

Primary outcome

The primary outcome for the study is the incidence of rescue oxygenation attempts for hypoxaemic events during tubeless airway surgery comparing high flow nasal oxygen to low flow oxygen.


$A583,000 from Society for Paediatric Anaesthesia in New Zealand and Australia, Australian and New Zealand College of Anaesthetists and Thrasher Research Foundation.

Related publications

Humphreys S, von Ungern-Sternberg BS, Skowno J, Williams T, Taylor J, Taverner F, Gibbons K, Burgoyne L, Sommerfield D, Stephens P, Hallett B, Vijayasekaran S, Slee N, Burns H, Sowa M, Davidson A, Schibler A. High-flow oxygen for children's airway surgery: randomised controlled trial protocol (HAMSTER). BMJ Open. 2019 Oct 14;9(10):e031873. doi: 10.1136/bmjopen-2019-031873. PMID: 31615801; PMCID: PMC6797255.

Trial registration

Australian New Zealand Clinical Trials Registry registration number: ACTRN12618000949280


For further information about this study, please contact the HAMSTER principal investigator, Dr Susan Humphreys by email.

Last updated 10:40 6.03.2023