Induced hypertension during general anaesthesia for thrombectomy involving stroke patients

Induced hypertension during general anaesthesia for thrombectomy involving stroke patients


MASTERSTROKE trial: Management of Systolic blood pressure during Thrombectomy by Endovascular Route for acute ischaemic STROKE

MASTERSTROKE is a pragmatic, prospective, double blind, randomized, multicentre clinical trial. The aim is to assess the influence of induced hypertension (IH) during general anaesthesia for thrombectomy involving stroke patients. The primary outcome is functional recovery at 90 days as measured by the modified Rankin Scale. Anaesthetists will be asked to target a systolic blood pressure target of 140 mm Hg or 170 mm Hg from case start until the target vessel is recanalised or case completion if recanalisation is not achieved.
For all the latest updates on the MASTERSTROKE Trial, follow @MASTERSTROKE_nz on Twitter.

Principal investigator

Dr Doug Campbell


The MASTERSTROKE trial has recruited 260 participants at three New Zealand sites; (Te Whatu Ora Te Toka Tumai Auckland, Te Whatu Ora Waitaha Canterbury (Christchurch) and Te Whatu Ora Capital and Coast (Wellington).  University Medical Centre, Groningen, Netherlands have secured local funding and are proceeding with ethics and regulatory approvals. Princess Alexandra Hospital in Brisbane has ethical approval and is close to recruitment. Gold Coast University Hospital and North Shore Hospital, Sydney hope to start recruitment soon.

The Australian ethics application is being initiated by Allison Kearney and David Highton at Princess Alexandra Hospital in Brisbane. Australian sites wanting more information or wishing to register interest to email Doug Campbell.


The trial has received a total of $NZ490,000 from the Auckland District Health Board Research Trust, The Auckland Medical Research Foundation and the Neurological Foundation of New Zealand in order to fund the project office, database and New Zealand recruitment. Dr Doug Campbell is supported by a two year Senior Clinical Research Fellowship from the Neurological Foundation of New Zealand to help administer the trial.

Trial registration

Australian New Zealand Clinical Trials Registry registration number: ACTRN12619001274167


Deng C, Campbell D, Diprose W, Eom C, Wang K, Robertson N, Short TG, Brew S, Caldwell J, McGuinness B, Barber PA. A pilot randomised controlled trial of the management of systolic blood pressure during endovascular thrombectomy for acute ischaemic stroke. Anaesthesia. 2020 Jun;75(6):739-746. doi: 10.1111/anae.14940. Epub 2019 Dec 12. PMID: 31833064.

Participating hospitals

New Zealand hospitals
Auckland City Hospital
Christchurch Hospital

For more information

For further information about this study, please contact the MASTERSTROKE principal investigator, Dr Doug Campbell by email.

Last updated 16:09 19.12.2023