Chronic pain affects millions worldwide, often with limited treatment options and significant side effects. Recent breakthroughs in neuromodulation show promising potential in controlling glial cells - key players in chronic pain maintenance. This project aims to investigate a novel approach using direct current (DC) stimulation, which, unlike conventional pulsed waveforms, may provide a more effective method to modulate glial activity in the spinal cord.
We will use a well-established rat model of chronic pain to test the efficacy of DC stimulation. By comparing traditional electrical stimulation methods with DC waveforms, we aim to determine whether DC can reduce pain-related behaviors and influence glial function more effectively. Advanced cell imaging and transcriptomics will allow us to understand how these electrical fields alter cellular responses in the spinal cord.
This research could lay the foundation for a new drug-free therapy, offering long-term relief for chronic pain sufferers.
Associate Professor Vahid Mohabbati, Dr Mohammadkazem Papan, Sydney Pain Research Centre, NSW; Associate Professor Gila Moalem-Taylor, Dr Felix Aplin, University of NSW.
The project was awarded A$65,940 funding through the ANZCA research grants program for 2025.