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Planned library system outage: Access to library e-resources - including all e-books and e-journals - will be impacted by a system upgrade on Wednesday, 18 February 2026 from 8AM - 12PM AEDT / 10AM - 2PM NZDT.

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The college will be closed from 2pm (AEDT) on Wednesday 24 December 2025 until Monday 5 January 2026. We wish you a happy and safe festive period.

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CTN endorsed studies and how to apply

Endorsement of a clinical trial by the ANZCA CTN is a powerful badge of quality, adding to the competitiveness of studies in peer-reviewed grant processes, the acceptability of protocols to ethics committees, investigators and study participants, and the attractiveness of completed projects to journal editors and scientific meeting convenors.

A researcher in protective gear, including gloves and safety glasses, examines a vial in a laboratory setting, with labeled study materials in the background.

CTN endorsed studies

The CTN developed the first endorsement guidelines in 2012 and officially began endorsing studies in 2013.  Explore the studies we have endorsed over the decade. 

Endorsed studies

Principal InvestigatorStudyYear
Dr Luke PerryThe Pulmonary Artery Catheters in Adults Undergoing Low-Risk Cardiac Surgery (PUMA) master protocol2026
Professor Robert Sanders (NSW)DECIDE study: Dexmedetomidine in Cardiac surgical Intraoperative Drug Evaluation2023
Dr Daniel Frei (NZ)Perioperative Medicine Platform trial (PROMPT) master protocol2025
Professor Robert Sanders (NSW)DECIDE study: Dexmedetomidine in Cardiac surgical Intraoperative Drug Evaluation2023
Dr Luke Perry (Vic)Pulmonary catheters in adults undergoing low risk cardiac surgery (The PUMA Pilot): a multicentre, randomised, controlled, consumer co-designed, Vanguard, pilot and feasibility clinical trial2023
Professor David Sturgess and Dr Judy Munday (QLD)The Glow Trial: Implementing Guidelines for hypothermia prevention with Local adaptation to keep periOperative patients Warm2023
Dr Daniel Frei (NZ)The HOT-ROX trial: The Hospital Operating Theatre- Randomised OXygen trial2022
Professor Trisha Peel (Vic)CALIPSO trial: The Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study2022
Professor Kate Leslie (AO) (Vic)The SNAPP study: Suggamedex, Neostigimine and Postoperative Pulmonary Complications2020
Dr Benjamin Moran (NSW)The PAIN-ICU Study: PAIN in Survivors of Intensive Care Units. A prospective, multi-centre observational Cohort study to determine the incidence, risk factors and impact of chronic pain in critically ill adult patients discharged from ICU2020
Professor Paul Myles (Vic)Prevalence of Asymptomatic SARS-Cov-2 Infection in Elective Surgical Patients in Australia: a prospective cohort study.2020
Dr Raymond Hu (Vic)TRICS IV trial: Restrictive versus Liberal Transfusion in Younger Patients Undergoing Cardiac Surgery.2019

Associate Professor Susan Humphreys (Qld)

HAMSTER trial: High-flow oxygen for children’s airway surgery: A randomised controlled trial.2019

Professor Paul Myles (Vic)

DECS-II trial: Comparative effectiveness of dexamethasone for cardiac surgery2019
Professor Michael Reade (QLD)CLIP-II: Cryopreserved vs. Liquid Platelets trial2018
Professor Paul Myles (Vic)TRIGS trial: Tranexamic acid to Reduce Infection after Gastrointestinal Surgery2018
Dr Thomas Painter (SA)POISE-3 Trial: PeriOperative ISchemic Evaluation-32018
Professor Tomás Corcoran (WA)LOLIPOP: Lidocaine and chronic post-surgical pain in breast cancer surgery2018
Professor Bernhard Riedel (Vic)VAPOR-C Study: Volatile Anaesthesia and Perioperative Outcomes Related to Cancer2018
Associate Professor Gordon Doig (NSW)Intravenous amino acid therapy for kidney protection in cardiac surgery patients: a multicentre randomised controlled trial.”2018
Dr Doug Campbell (NZ)MASTERSTROKE: Management of Systolic blood pressure Thrombectomy by Endovascular Route for acute ischaemic STROKE2018
Associate Professor David Canty (Vic)ECHONOF III trial: A pragmatic multicentre randomised trial of focused cardiac ultrasound prior to surgery for hip fracture.2018
Associate Professor Lachlan Miles (Vic)NATO study: Non-Anaemic Iron Deficiency and Tranfusion Outcomes after Colorectal Cancer Surgery2018
Associate Professor Jai Darvall (Vic)Chewy: A randomised non-inferiority trial of chewing gum versus ondansetron to treat postoperative nausea and vomiting in female patients after breast and laparoscopic surgery.2016
Professor Yahya Shehabi (Vic)Perioperative Dexmedetomidine in High Risk Cardiac Surgery Evaluation - DiCE II Trial; Muliticenter Multinational Randomised Double-Blind Placebo Controlled Trial.2017
Dr Ianthe Boden (Tas)CHESTY: (CHEST infection prevalence following surgerY) – an international multicenter observational trial.2017
Professor Guy Ludbrook (SA)Advanced Recovery Care2017
Dr Nico Terblance (Tas)PADDI-Hypothalamus Pituitary Adrenal Axis Sub-Study.2017
Professor Philip Peyton (Vic)ROCKet Study: Reduction Of Chronic Post-surgical Pain with Ketamine2016
Professor Andrew Davidson (Vic)T-REX Study: Neurodevelopmental outcome after sevoflurane versus dexmedetomidine/ remifentanil anaesthesia in infancy2016
Professor Professor Yahya Shehabi (Vic)DiCE 1: Dexmedetomidine in High Risk Cardiac Surgery Evaluation2016
Professor Paul Myles (Vic)ITACS Trial: IV iron for Treatment of Anaemia before Cardiac Surgery.2015

Professor Paul Myles (Vic)

EPICS-Australasia: Epidemiology of Critical care provision after Surgery2015

Dr Warren Pavey (WA)

Prothrombinex vs FFP for bleeding after cardiopulmonary bypass study2014
Professor Alan Merry (NZ)Z- bugs trial: Apprehending micro-organisms injected during anaesthesia.2014
Professor David Story (Vic)C-CaFe Trial: Colorectal cancer, anaemia and iron management2015
Professor Paul Myles (Vic)CELSUS trial: high-dose dexamethasone in cardiac surgery
2015
Professor Tomás Corcoran (WA)PADDI Trial: Perioperative ADministration of Dexamethasone and Infection trial2014
Professor Paul Myles (Vic)Statins Before Surgery Study 3S2014
Dr Richard Halliwell (NSW)International Surgical Outcomes Study (ISOS)2013
Dr Doug Campbell (NZ)NeuroVISION Study: Neurological impact of vascular events in noncardiac surgery patients cohort evaluation study.2013
Dr Mark Shulman (Vic)METS: Measurement of Exercise Tolerance for Surgery.2013